The present study was designed to develop a transdermal patch using natural polymers like psyllium and guar gum in combination with semisynthetic polymer like hydroxy propyl methyl cellulose K4M. Captopril was used as a model drug. FTIR study was carried out to study drug excipients compatibility. The transdermal patches using different polymer concentrations were prepared by solvent casting method. The prepared patches were evaluated for parameters like drug content, folding endurance, thickness and drug release etc. The optimized patches consisting of HPMC K4M (40 mg) and psyllium (60 mg) had drug content of 99.14%, folding endurance of 164±1 and drug release of 97.75±0.56%. HPMC K4M (65 mg) and guar gum (35 mg) had drug content of 99.23%, folding endurance of 159±1 and drug release of 98.19±0.22%. The in-vitro drug release study showed that drug was released in a controlled manner for a period of 12 hrs. Hence it can be concluded that natural polymers like psyllium and guar gum could be successfully used for preparation of transdermal patch.
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